Expeditious Synthesis of a Glycopeptide Library

Short proteoglycan fragments are of great importance for biochemical research. The solid-phase synthesis such glycopeptides relies on excessive use glycosylated amino acids, extended reaction times, and additional post-assembly deprotection protocols. We employed high-shear mixing expedient equimolar O-glycopeptide assembly. further developed a stirring-based the solid support, thus completing glycopeptide library in minimal amount time purification hurdles.